Synthesis and biological properties of a novel cephalosporin FR86521 having potent activity against methicillin-resistant Staphylococcus aureus (MRSA)
نویسندگان
چکیده
biotics having low toxicity and high activities against both Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative bacteria including Pseudomonas aeruginosa (P. aeruginosa), which are the main bacteria causing nosocomial infections, are now urgently required. Recently, we introduced cefoselis (CFSL)4'5), which shows potent broadspectrum activity against both Gram-positive bacteria,
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In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci.
We examined the activity of CB-181963, a novel cephalosporin, against methicillin-resistant Staphylococcus aureus (MRSA) (n = 200), methicillin-susceptible S. aureus (MSSA) (n = 50), glycopeptide-intermediate Staphylococcus species (GISS) (n = 47), and VRSA (n = 2) isolates. CB-181963 exhibited MIC profiles similar to those of linezolid against MRSA and GISS; however, activity against MSSA was ...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 52 12 شماره
صفحات -
تاریخ انتشار 1999